BIOENERGETICS-BASED MODELING OF PLASMODIUM FALCIPARUM METABOLISM REVEALS ITS ESSENTIAL GENES, NUTRITIONAL REQUIREMENTS, AND THERMODYNAMIC BOTTLENECKS.

Novel antimalarial therapies are urgently needed for the fight against drug-resistant parasites.The metabolism of malaria parasites in infected cells is an attractive source of drug targets but is rather complex.Computational methods can handle this complexity and allow integrative analyses of cell metabolism.In this study, we present a genome-scal

The issue of complex regeneration of old pre-cast concrete apartment buildings is still a current task of everyday construction practice in click here the Czech Republic.When designing a new thermal insulation for the envelope of these buildings, we often encounter with critical assembly details.The correct solution of these details requires a deta

Machined surfaces are rough from a microscopic perspective no matter how finely they are finished.Surface roughness is an important factor to consider during production quality control.Using modern techniques, surface roughness measurements are beneficial for improving machining quality.With optical imaging of machined surfaces as input, a convolut

A correlation with phonons sustained by a pair of electromechanical resonators that differ both in size and frequency is demonstrated.In spite of the electromechanical resonators being spatially distinct, they can still be strongly dynamically coupled via here a classical analogue of the beam splitter interaction with a cooperativity exceeding five